Diurnal to present research into the treatment of CAH at ENDO 2022

7th June 2022

Diurnal Group plc (AIM: DNL), the specialty pharmaceutical company targeting patient needs in chronic endocrine (hormonal) diseases, will be presenting research findings on the treatment and management of congenital adrenal hyperplasia (CAH) at this year’s American Endocrine Society meeting, ENDO 2022, which will be taking place between 11-14 June 2022 in Atlanta, USA.

Over the four-day meeting, the following topics will be presented:

  • Comparison of prednisolone versus hydrocortisone modified-release hard capsules (Efmody®) in the treatment of CAH.

  • A de novo model for measuring long-term health effects of hydrocortisone modified-release hard capsules in adult and adolescent patients with classic CAH.

CAH occurs when the production of cortisol from the adrenal gland is limited due to a genetic deficiency. CAH is associated with over-production of male sex hormones resulting in ambiguous genitalia at birth, precocious sexual development, infertility in men and women, and increased mortality through adrenal crisis.

Around 450,000 people globally are estimated to be living with a CAH disorder yet there is no standard treatment. Instead, a variety of steroids are used but data shows around two thirds of people living with CAH still have problems with disease control [i] .

Richard Bungay, Interim Chief Executive Officer of Diurnal commented:

"These presentations at ENDO follow our very well attended presentations at the European Congress of Endocrinology meeting in Europe last month. Diurnal is committed to supporting research into diseases of cortisol deficiency and developing solutions to support patients with these life-long disorders. The interest we have received from the world’s leading endocrinologists demonstrates the progress we are making in the treatment and management of diseases of cortisol deficiency.”

For further information, please visit www.diurnal.co.uk or contact:

Diurnal Group plc

+44 (0)20 3727 1000

Richard Bungay, Interim Chief Executive Officer

Panmure Gordon (UK) Limited (Nominated Adviser and Joint Corporate Broker)

+44 (0)20 7886 2500

Corporate Finance: Freddy Crossley, Emma Earl

Corporate Broking: Rupert Dearden

Stifel Nicolaus Europe Limited (Joint Corporate Broker)

+44 (0) 20 7710 7600

Healthcare Investment Banking: Nicholas Moore, Samira Essebiyea, William Palmer-Brown

Corporate Broking: Nick Adams, Nick Harland

FTI Consulting (Media and Investor Relations)

+44 (0)20 3727 1000

Simon Conway

Victoria Foster Mitchell

Alex Davis

Vane Percy & Roberts (Medical Communications)

+44 (0) 173 782 1890

Simon Vane Percy

Notes to Editors

About Diurnal Group plc

Diurnal Group plc is a European, UK-headquartered, specialty pharmaceutical company dedicated to developing hormone therapeutics to aid lifelong treatment for rare and chronic endocrine conditions, including congenital adrenal hyperplasia, adrenal insufficiency, hypogonadism and hypothyroidism. Its expertise and innovative research activities focus on circadian-based endocrinology to yield novel product candidates in the rare and chronic endocrine disease arena.

For further information about Diurnal, please visit www.diurnal.com

Date of Preparation: June 2022 Code: CORP-GLO-0039

[i] Mallappa, A., Merke, D.P. Management challenges and therapeutic advances in congenital adrenal hyperplasia. Nat Rev Endocrinol 18, 337–352 (2022). https://doi.org/10.1038/s41574-022-00655-w

Diurnal Limited (Company Number: 05237326) is registered in England & Wales. Registered office: Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, UK.